Ubc-GFP mice were injected with s.c. EL4-OVA lymphoma cells and then infused i.v. with large numbers (i.e., 107) of control or Ptpn22–/– memory phenotype OT-1 T cells, which were sufficient to clear the primary tumor (Supplemental Figure 3). This evidence concerns the gene PTPN22 and neoplasm.