For instance, lnc-LBCS could dramatically attenuate bladder cancer initiation and chemo-resistance via guiding hnRNPK-EZH2 complex to the SOX2 promoter and mediating histone H3 lysine 27 trimethylation (H3K27me3) [29]. The gene discussed is LNC-LBCS; the disease is urinary bladder cancer.