INS and diabetes mellitus: As hemoglobin A1c (HbA1c) levels decrease, hypoglycemia risk increases for patients with diabetes who depend on insulin therapy.1,2 Nonsevere hypoglycemia—often a daily occurrence for many patients—impairs well-being and reduces productivity, and severe hypoglycemia may result in seizures, coma, or death.3–7 In the international Hypoglycemia Assessment Tool (HAT) study, which involved ∼8000 adults with type 1 diabetes (T1D), the estimated annual rate of any hypoglycemia was 73.3 episodes per patient-year.