The use of sotagliflozin in combination with insulin also significantly reduced mean HbA1c, weight, insulin doses, and SBP (in patients with SBP ≥130 mmHg at baseline).12,13 As shown in a continuous glucose monitoring (CGM) substudy, sotagliflozin also reduced multiple measures of glycemic variability and significantly increased time in range, demonstrating reduced time in hyperglycemia without an increase in time <70 mg/dL.27 These changes were accompanied by significant improvements in treatment satisfaction and diabetes distress scales in the overall study populations.12,13. The gene discussed is INS; the disease is diabetes mellitus.