It is believed that A2AR has a unique control of the maintenance and extraction of working memory in the globus pallidus and medial prefrontal cortex neurons, and A2AR antagonists can alleviate the cognitive impairment of PD.49 In addition, A2AR antagonists can also reduce l‐dopa induced dyskinesia.50 Therefore, adenosine A2AR antagonists play an important role in the treatment of PD. The gene discussed is ADORA2A; the disease is Dyskinesia.