GRIN2B and Alzheimer disease: In addition, there is an association between isoflurane exposure and spatial memory impairment, and declines in NR2B levels and increases in Aβ and P‐tau levels may be achieved by activating A1AR.39 However, Yao et al40 believed that Aβ_(1‐42) induced AD through the CD73 specific inhibitor APCP (α,β‐methylene adenosine‐5′‐diphosphate) and that it can significantly enhance the learning ability and working‐memory capacity and increase the central excitability of AD mice, which may be related to the reduction of the content of adenosine outside the hippocampal cells.