ADORA2A and Cognitive impairment: It is believed that A2AR has a unique control of the maintenance and extraction of working memory in the globus pallidus and medial prefrontal cortex neurons, and A2AR antagonists can alleviate the cognitive impairment of PD.49 In addition, A2AR antagonists can also reduce l‐dopa induced dyskinesia.50 Therefore, adenosine A2AR antagonists play an important role in the treatment of PD.