Meller et al, showed that rapid degradation of BIM mediated short‐term ischaemic tolerance in cultured neurons 14; Arumugam et al, found that gamma‐secretase‐mediated notch signalling induced neuronal cell death via NF‐κB‐BIM pathway in ischaemic stroke.15 In addition, studies also showed that the c‐Jun N‐terminal protein kinase signalling pathway mediated neurol apoptosis via interacting with BIM in focal cerebral ischaemia.16 Here, BCL2L11 is linked to ischemic stroke.