Currently, lncRNAs are found to exhibit differential functions in various human diseases, such as ischaemic stroke, hepatocellular carcinoma and breast cancer, and demonstrate the ability to affect cell transformation, metastasis and apoptosis.7, 8, 9 Previous study has revealed that SNHG6 promoted oesophageal squamous cell carcinoma cell proliferation and inhibited cell apoptosis.10 However, the functions and biological mechanisms of SNHG6 in the neuronal cells under ischaemic stroke condition have not yet been explored. The gene discussed is SNHG6; the disease is ischemic stroke.