Structural analyses of the human and yeast spliceosome in the RNA‐bound B‐activated Complex suggest that cancer‐associated mutations in SF3B1 change the charge and shape of the corresponding amino acid residues that results in direct disruption of the local interaction with pre‐mRNA.46, 60, 61, 62 This results in a spatial shift in the pre‐mRNA by approximately 10 nucleotides, consistent with bioinformatic predictions. Here, SF3B1 is linked to cancer.