Indeed, a more recent study including 1540 patients with AML performed targeted sequencing of 111 genes and cytogenetic analysis and classified 11 subgroups,34 including ~18% of AML patients with mutations in chromatin modifiers (ASXL1, STAG2, BCOR, MLLPTD, EZH2, and PHF6) and spliceosome genes (SF3B1, SRSF2, U2AF1, and ZRSR2). This evidence concerns the gene STAG2 and acute myeloid leukemia.