PRMT5 and myelodysplastic syndrome: The general function of PRMTs in RNA splicing regulation can be inferred from observation that genetic loss of Prmt5 caused global splicing alteration in murine neural stem/progenitor cells126 and murine hematopoietic stem cells.127, 128 PRMT5 is overexpressed in a variety of human tumor types and several orally bioavailable PRMT5 inhibitors and, most recently, a novel type‐I PRMT inhibitor are now in early‐phase clinical trials for patients with non‐Hodgkin's lymphoma, advanced solid tumors and in low‐risk MDS (Table 1).