Recently, several candidate novel loci have been identified in a GWAS for POAG (e.g., ABCA1, AFAP1, GMDS, PMM2, TGFBR3, FNDC3B, ARHGEF12, GAS7, FOXC1, ATXN2, TXNRD2); PACG (e.g., EPDR1, CHAT, GLIS3, FERMT2, DPM2-FAM102); and exfoliation syndrome (XFS) glaucoma (CACNA1A) [8,9]. Here, ARHGEF12 is linked to exfoliation syndrome.