When stratified by ethnicity, a significant association between MTHFR A1298C polymorphism and increased risk of glaucoma was detected among Asians (C vs. A: OR = 0.826, 95% CI 0.692-0.987, p = 0.036; CC vs. AA: OR = 0.456, 95% CI 0.268-0.777, p = 0.004; and CA vs. AA: OR = 705, 95% CI 0.541-0.918, p = 0.010) and Caucasians (CC vs. CA+AA: OR = 1.443, 95% CI 1.019-2.044, p = 0.039). This evidence concerns the gene MTHFR and glaucoma.