In addition, when stratifying by types of glaucoma, we found that MTHFR A1298C was significantly associated with POAG risk under heterozygote model (CA vs. AA: OR = 0.746, 95% CI 0.570-0.976, p= 0.033), but not with PXFG and NTG (Table 4). Here, OPA1 is linked to open-angle glaucoma.