The role of CREB3L2 in cancer is mainly represented by the specific translocation t(7;16)(q33;p11) that results in the creation of the chimeric gene FUS-CREB3L2, which is responsible for low-grade fibromyxoid sarcoma (LGFMS); a rare, slow-growing type of cancer that usually forms in the deep soft tissues of the legs or trunk (chest and abdomen) (Panagopoulos et al., 2007; Bartuma et al., 2010). The gene discussed is FUS; the disease is cancer.