CREB3L2 and malignant glioma: Participation of CREB3L2 in cell survival was also reported in mouse malignant glioma GL261 cells (Sheng et al., 2010), where CREB3L2 was identified as one of the 12 genes required for expression of ATF5 (activating transcription factor 5), an anti-apoptotic factor which plays a role in cell survival (Monaco et al., 2007).