In a second study, hippocampal neurons from mice transgenic for the Swedish mutation of amyloid precursor protein (APP) and a mutant presenilin 1 subunit of γ-secretase, where both mutations are associated with early onset Alzheimer’s disease, revealed extensive Golgi fragmentation by optical microscopy (Joshi et al., 2014). This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.