The inhibition of Ras PM localization could block all oncogenic activity (Baines et al., 2011), which implies NATs are promising lead compounds for treating drug-resistant cancer related to P-glycoprotein (P-gp) mediated drug efflux, and it was found that NATs exhibited significant cytotoxicity toward SW620 Ad300 cell line in which P-gp was overexpressed (Salim et al., 2014). The gene discussed is PGP; the disease is cancer.