In conclusion, we identified parental height and syndromic disease, pubertal status and BMI, end-stage renal disease and dialysis, GH treatment and the country of residence as key factors impacting on growth in children with CKD whereas renal anemia, metabolic acidosis and CKD-MBD did not appear to be of relevant influence. The gene discussed is GH1; the disease is Marchiafava-Bignami disease.