We observed a significant increase of cleaved PARP levels in ALK dependent neuroblastoma cell lines, such as CLB-BAR and CLB-GE in response to alectinib treatment, while no difference was observed in SK-N-AS (11q-del, K-RasQ61K), CLB-PE and IMR-32 control cell lines (Figure 3A and Supplementary Figure 3). The gene discussed is CLYBL; the disease is neuroblastoma.