More importantly, after silencing LNMAT1 expression in MM cells with shRNAs (Figure 1F, P < 0.05), the mRNA expression levels of MMP-2, MMP-9, and N-cadherin, which are markers of tumor invasion-metastasis cascade, were found to be downregulated by qRT-PCR. The gene discussed is MMP2; the disease is Miyoshi myopathy.