However, even these cytokines are frequently increased in the blood of MCL patients, with some, including sIL-2Ra and IL-8, being recognized as adverse prognostic factors (11, 12) We have validated increased expression by MCL-RL of IL-6 and IP-10, by standard EIA (Supplemental Figure 2). The gene discussed is CXCL8; the disease is mantle cell lymphoma.