The DEGs were mainly enriched in pathways of complement and coagulation cascades (hsa04610), malaria (hsa05144), prion diseases (hsa05020), fluid shear stress and atherosclerosis (hsa05418), AGE-RAGE signaling pathway in diabetic complications (hsa04933), vascular smooth muscle contraction (hsa04270), IL-17 signaling pathway (hsa04657), leukocyte transendothelial migration (hsa04670), protein digestion and absorption (hsa04974) and drug metabolism—cytochrome P450 (hsa00982) (Table 3; Fig. 2D). Here, RENBP is linked to prion disease.