As the only upregulated hub gene, PRC1 is involved in the process of cytokinesis and is upregulated in breast cancer, hepatocellular carcinoma, and lung cancer (Jiang et al., 1998; Liu et al., 2018; Shimo et al., 2007; Zhan et al., 2017a). This evidence concerns the gene PRC1 and hepatocellular carcinoma.