SPINK5 and Decreased circulating total IgM: Current literature reports nine PIDs to be possibly related to the atopic syndrome, including autosomal dominant HIES (AD-HIES; STAT3), autosomal recessive HIES (AR-HIES; DOCK8), Comèl Netherton syndrome (SPINK5), hypogammaglobulinemia, selective IgA deficiency (SIgAD), IgM deficiency, IPEX (FOXP3), chronic granulomatous disease (CGD; CYBA, CYBB, NCF1, NCF2 and NCF4), and phospholipase C gamma 2 (PLCG2) gene associated antibody deficiency and immune dysregulation (PLAID; PLCG2), and 28 additional genetic PID conditions [27, 37].