Tumor-derived circulating extracellular vesicles presenting in HNSCC serum patients seems to play a role in tumor evasion from cell death, being responsible for the demise of activated CD8+ T cells in the peripheral circulation, possibly through the presence of FasL (member of the tumor necrosis factor (TNF) Family) on the vesicles [47]. The gene discussed is FASLG; the disease is neoplasm.