OSBP2 has been reported to be essential for the post-meiotic differentiation of germ cells, while the lack of OSBP2 (ORP4) caused male infertility owing to oligo-astheno-teratozoospermia (Charman et al., 2014; Udagawa et al., 2014). Here, OSBP2 is linked to Abnormal sperm morphology.