In line with our results, a previous work demonstrated that the HDAC7 gene was hypomethylated and overexpressed in islets from donors with T2D (Dayeh et al., 2014), which could have pathological implications given that Hdac7 overexpression in rat islets and β-cell lines resulted in impaired insulin secretion (Daneshpajooh et al., 2017). The gene discussed is INS; the disease is type 2 diabetes mellitus.