Indeed, analysis of chromosome breakpoints caused by the RAG/ESC complex, using linear amplification-mediated, high-throughput genome-wide sequencing [LAM-HTGTS; (39)] showed a significant overlap between cut-and-run-mediated breakpoints and those observed in ETV6/RUNX1-positive ALL patients (22, 40). Here, ETV6 is linked to acute lymphoblastic leukemia.