More recently, the chemokine CCL20 was identified as a TRAIL/NF-κB inducible target gene in resistant pancreatic cancer cells that indirectly modulated TRAIL resistance in mice by recruiting peripheral blood mononuclear cells (PBMCs), which further increased TRAIL resistance of CCL20-producing pancreatic cancer cells (94). This evidence concerns the gene NFKB1 and familial pancreatic carcinoma.