MMP12 activity could be mimicked by a recombinant C-terminal domain peptide, named SR20, that could induce TRAIL-mediated apoptosis both in oncogenic mutated KRAS and WT murine and human NSCLC cells as demonstrated in vitro and in orthotopically implanted mice and a KRAS-induced murine mouse model. This evidence concerns the gene TNFSF10 and non-small cell lung carcinoma.