IL8 produced by tumor cells or recombinant IL8 also was shown to suppress TRAIL-induced apoptosis in prostate cancer cells by up-regulation of the anti-apoptotic proteins cFLIP(S) and cFLIP(L) in a CXCR2 and NF-κB-dependent way. The gene discussed is CXCL8; the disease is Familial prostate cancer.