Moreover, it was shown that adoptive transfer of tumor-specific CD8+ CTLs producing IFNγ and TNFα together with recombinant TRAIL/agonistic mAb therapy effectively induced apoptosis in CT26 tumor cells in mice, whereas TRAIL alone was ineffective, indicating cooperative activity between tumor infiltrating immune cells and TRAIL therapy (84). This evidence concerns the gene TNFSF10 and neoplasm.