CD4+ T cells from SLE patients are characterized by increased H3K27me3 and decreased H3K18ac levels at the IL2 promoter region as compared to healthy controls (26), which is (at least partially) mediated by the interaction between CREMα and HDAC1 at the IL2 but not the IL17A promoter. The gene discussed is CD4; the disease is systemic lupus erythematosus.