CD4+ T cells from SLE patients are characterized by increased H3K27me3 and decreased H3K18ac levels at the IL2 promoter region as compared to healthy controls (26), which is (at least partially) mediated by the interaction between CREMα and HDAC1 at the IL2 but not the IL17A promoter. This evidence concerns the gene IL17A and systemic lupus erythematosus.