SUCNR1 and hypertensive disorder: As already discussed, the succinate receptor SUCNR1/GPR91 is known to play a role in several diseases including diabetic retinopathy (108), diabetic renal disease (114), hypertension (113, 115), atherothrombosis (116), neuroinflammation (111), rheumatoid arthritis (114), and metabolic dysfunctions (174).