Our study revealed that DAPA successfully inhibited hyperglycaemia-induced ECM deposition in the kidneys of diabetic mice, attenuated EMT of tubular epithelial cells under hyperglycemic conditions, and suppressed the level of the profibrotic factors STAT1 and TGFβ1 both in vivo and in vitro. Here, TGFB1 is linked to Hyperglycemia.