Additional CTE based classification: l. Probable CTE ll. Possible CTE lll. Unlikely CTE
*CTE Biomarkers: (1) Cavum septum pellucidum (2) Normal amyloid-beta CFS level, as opposed to CSF amyloid beta elevation in AD (3) Elevated p-tau/total tau ratio compared to age-matched controls (4) Positive Tau neuroimaging such as Tau-PET imaging (5) Negative amyloid imaging, such as amyloid PET Brain scan, in order to delineate from possible AD (6) Cortical thinning (7) Cortical atrophy. Here, MAPT is linked to Alzheimer disease.