In the 4-week CRS model, c-Fos activation in the HIP-CA1, HIP-CA2, CC-1, cingulate cortex area 2 (CC-2), MC-1, MC-2, granular insular cortex (IC-Gi), piriform cortex (Pir), PAG-DM, mediodorsal thalamic nucleus (TH-MD), central medial thalamic nucleus (TH-CM), dorsomedial hypothalamic nucleus (HyTH-DM), ventromedial hypothalamic nucleus (HyTH-VM), HyTH-LH, and posterior hypothalamic area (HyTH-PH) was significantly increased only after AP treatment. This evidence concerns the gene FOS and congenital rubella syndrome.