HMGB1 and Sepsis: Previous reports show that the main deacetylation site of HMGB1 is lysine residues (28–30) (Hwang et al., 2015) in sepsis-induced murine macrophage or lysine residues (55, 88, 90, and 177) (Rabadi et al., 2015) in ischemic endothelial cells.