In addition, SIRT1 has been reported to form a stable complex with HMGB1 and to directly interact with HMGB1 via its N-terminal lysine residues (28–30) in murine macrophage RAW264.7 cells, thereby inhibiting HMGB1 release to improve survival in an experimental model of sepsis (Hwang et al., 2015). Here, HMGB1 is linked to Sepsis.