SIRT1 and Sepsis: In addition, SIRT1 has been reported to form a stable complex with HMGB1 and to directly interact with HMGB1 via its N-terminal lysine residues (28–30) in murine macrophage RAW264.7 cells, thereby inhibiting HMGB1 release to improve survival in an experimental model of sepsis (Hwang et al., 2015).