Apart its effects on tumor growth, Amblyomin-X displays antiangiogenic properties and inhibits vascular endothelial growth factor A (VEGF-A)-induced angiogenesis in both the dorsal subcutaneous tissue of mice and the chicken chorioallantoic membrane by modulation of endothelial cell proliferation and adhesion, especially of membrane expression of platelet-endothelial cell adhesion molecule-1 (PECAM-1) (Drewes et al., 2012, 2015), suggesting the possible application of Amblyomin-X as a local inhibitor to undesired neovascularization. This evidence concerns the gene PECAM1 and neoplasm.