In addition, direct FXa inhibitors, including TAP, could potentially be used in prevention of other diseases, such as atherosclerosis or atrial fibrillation, because FXa as well as thrombin are involved in mediation of protease-activated receptor signaling and modulation of cellular mechanisms in the abovementioned pathophysiological processes (Spronk et al., 2014). Here, F10 is linked to atherosclerosis.