Another tick Kunitz domain protease inhibitor with promising antithrombotic and anti-tumor therapeutic usage, Ixolaris, a two-Kunitz domain inhibitor that displays homology to the tissue factor (TF) pathway inhibitor (TFPI), was obtained by screening the cDNA library derived from salivary glands of Ixodes scapularis (Francischetti et al., 2002, 2004). The gene discussed is TF; the disease is neoplasm.