HIF1A and neoplasm: To further identify the effects of TSL on the expression of proangiogenic factors, we detected VEGF, Platelet derived growth factor (PDGF), Epidermal Growth Factor (EGF), Basic Fibroblast Growth Factor (bFGF), and Hypoxia-Inducible Factor-1α (HIF-1α) in a hypoxia condition to imitate tumor microenvironment.