ERBB2 and breast carcinoma: For example, a member of the ERBB family ERBB2, also known as HER2, is amplified in about 30% of all breast cancers and overexpression of EGFR (epidermal growth factor receptor) is found in more than 50% of non-small cell lung cancer (Normanno et al., 2006; da Cunha Santos et al., 2011).