In agreement with our data, Nrf2 activation also reduced cellular stress such as oxidative stress and ER stress and ameliorated renal function in experimental ischemia–reperfusion (Bayrak et al., 2008; Yoon et al., 2008; Trujillo et al., 2013) and rhabdomyolysis-associated AKI (Zhao et al., 2016; Guerrero-Hue et al., 2017). The gene discussed is NFE2L2; the disease is acute kidney injury.