While there have been significant advances in knowledge regarding the role of CYP- and sEH-derived PUFA metabolites in cardiovascular disease; for review see Gross and Nithipatikom (2009), renal disease; for review see Imig (2018), and even metabolic syndrome and diabetes; for review see Huang et al. (2016), comparatively little is known about the impact of this pathway in the eye. This evidence concerns the gene EPHX2 and diabetes mellitus.