This however, contrasts with reports that hypoxia (which occurs in retinopathy) increases CYP2C expression in retinal endothelial cells (Michaelis et al., 2008), and that fenofibrate; which binds to and inhibits CYP2C, reduced retinal and choroidal neovascularization in PPARα−/− mice and augmented ω-3 PUFA protection via CYP2C inhibition (Gong et al., 2016b). The gene discussed is CYP2C19; the disease is retinal disorder.