VEGFA and retinal disorder: For a long time Müller cells were assumed to play a greater role in proliferative retinopathy than physiological angiogenesis, as the Müller cell-specific deletion of VEGF-A inhibited neovascularization in a mouse model of oxygen-induced retinopathy without affecting physiological vascularization or retinal morphology (Bai et al., 2009; Hu et al., 2014).