Although not definitively shown, it was suggested that the CYP2C8 expressed in a subset of Tie-2-expressing monocytes/macrophages was upregulated during oxygen-induced retinopathy, while, fitting with its regulation by hypoxia (Keserü et al., 2010), sEH expression was suppressed to result in an increased retinal epoxide:diol ratio (Shao et al., 2014). The gene discussed is EPHX2; the disease is retinal disorder.