PRNP and scrapie: In vitro, tetracycline prevented the PrP 106–126-mediated neurotoxicity and astroglial proliferation (Tagliavini et al., 2000); in vivo pretreatment with either tetracycline or Doxy in experimental scrapie reduced infectivity, delayed the onset of pathology, and increased survival when intracerebrally injected in Syrian hamsters (De Luigi et al., 2008).