It has been reported that TWEAK–Fn14 axis is involved in the pathogenesis of stroke via mediating neuronal apoptosis and breakdown of the BBB (Potrovita et al., 2004; Polavarapu et al., 2005; Yepes et al., 2005; Zhang et al., 2007; Haile et al., 2010). This evidence concerns the gene TNFRSF12A and Stroke.