EGFR and non-small cell lung carcinoma: For advanced non-small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) activating mutations (mainly exon 19 Del and exon 21L858R), EGFR tyrosine kinase inhibitors (EGFR-TKIs) have been shown to result in superior outcomes when compared with platinum-based chemotherapy (Mok et al., 2009; Mitsudomi et al., 2010; Zhou et al., 2011; Rosell et al., 2012; Shi et al., 2017).