Additional indirect strategies to interfere with the “sugar tooth” of cancer cells include the targeting of signaling pathways, which regulate GLUT expression, implicating regulators such as phosphoinositide 3-kinase (PI3K), mechanistic target of rapamycin (mTOR), c-Myc, and hypoxia inducible factor (HIF)-1α (Choi, 2017). This evidence concerns the gene MTOR and cancer.