The TME of 3-BP-administered tumor-bearing hosts displayed repolarization of macrophages to tumoricidal M1 phenotype, accompanied by an increase in CD4, CD8, CD49, CD25 (IL-2R), and CD62L, CD11c, and TLR-4 expressing cells, indicating an altered repertoire of NK cells and T lymphocytes in the TME and alleviation of tumor-associated immunosuppression (Yadav et al., 2017a). This evidence concerns the gene TLR4 and neoplasm.