AKT1 and neoplasm: Furthermore, the upregulated lipid metabolism of cancer cells is dependent on various factors, including hypoxia, tumor acidosis, and upregulated SREBP1c via signaling of Ras, extracellular signal-regulated kinase1/2, Phosphatase and tensin homolog, PI3K, and Protein kinase B (PKB or AKT) (Santos and Schulze, 2012; Beloribi-Djefaflia et al., 2016).