ALOX15B and Familial prostate cancer: Research in human prostate cells has shown that ALOX15B expression is down-regulated or lost in the precursor lesion HGPIN (high-grade prostate intraepithelial neoplasia) as well as in >70% of prostate cancers (Shappell et al., 1999; Jack et al., 2000; Tang et al., 2002; Tang et al., 2007; Suraneni et al., 2014).