Although these results support the notion that ALOX15 can directly contribute to atherosclerosis via LDL oxidation, subsequent studies performed in transgenic animal models reported both pro-atherogenic and anti-atherogenic roles for ALOX15 (Shen et al., 1996; Cyrus et al., 1999; Harats et al., 2000; Merched et al., 2008). Here, ALOX15 is linked to atherosclerosis.