In contrast to L1236 cells, inhibiting JmjC-domain-containing H3-K4 tri-demethylase lysine demethylase 5C (KDM5C) in the Hodgkin lymphoma cell line L428, which does not express ALOX15, upregulated ALOX15 expression through inducing H3-K4 trimethylation, histone acetylation, and STAT6 recruitment at the ALOX15 promoter (Liu et al., 2012). Here, ALOX15 is linked to Hodgkins lymphoma.