LDLR and atherosclerosis: Moreover, ALOX15B gene expression in CD14+ macrophages isolated from the human carotid endarterectomies was 500 times higher than ALOX15. To investigate the role of ALOX15B in promoting the development of atherosclerosis in vivo, researchers used lentiviral shRNA silencing and bone marrow transplantation to knock down Alox15b in LDL-receptor-deficient mice (Magnusson et al., 2012).