Inhibition of its acetyltransferase activity abrogated acetylation of both histones and STAT6 and strongly suppressed transcriptional activation of ALOX15. In the Hodgkin lymphoma cell line L1236, which constitutively express ALOX15, abolishing histone methyltransferase SMYD3 reduced ALOX15 expression by reducing di-/trimethylation of histone 3 lysine 4 (H3-K4), attenuated occupancy of STAT6, and diminishing histone H3 acetylation at the ALOX15 promoter. The gene discussed is STAT6; the disease is Hodgkins lymphoma.