Furthermore, our knowledge about this concept is growing due to increase in the number of studies that have described treatment of mice with ACE inhibitor preventing bone loss Gonçalves-Zillo et al. (2013), the protective effect of ACE inhibitors in PD-induced and arthritis-associated alveolar bone loss (Queiroz-Junior et al., 2015), and the mechanism by which AT1R inhibitor prevents inflammation and alveolar bone loss in periodontitis (Li et al., 2018). The gene discussed is ACE; the disease is periodontitis.