Furthermore, our knowledge about this concept is growing due to increase in the number of studies that have described treatment of mice with ACE inhibitor preventing bone loss Gonçalves-Zillo et al. (2013), the protective effect of ACE inhibitors in PD-induced and arthritis-associated alveolar bone loss (Queiroz-Junior et al., 2015), and the mechanism by which AT1R inhibitor prevents inflammation and alveolar bone loss in periodontitis (Li et al., 2018). This evidence concerns the gene ACE and Arthritis.