Accordingly, it has been shown that, in individuals with schizophrenia, a deficiency in brain derived neurotrophic factor- (BDNF-) mediated signaling combined with decreased levels of the GABA synthetizing enzyme, GAD67, results in reduced inhibitory neurotransmission of GABA neurons (i.e., basket cells) in the dorsolateral prefrontal cortex (Lewis et al., 2005; Kimoto et al., 2014). The gene discussed is BDNF; the disease is schizophrenia.