TACR1 and Stroke: This was until studies depleting neuropeptides or blocking the action of SP at the tachykinin NK1 receptor (NK1-r), to which SP binds preferentially, showed a ubiquitous role for this process in the genesis of cerebral edema following stroke and traumatic brain injury (TBI) (Vink et al., 2003; Nimmo et al., 2004; Turner et al., 2006, 2011; Donkin et al., 2009; Turner and Vink, 2012, 2014; Corrigan et al., 2016a).