Taken together, we have now successfully demonstrated the efficacy of NK1-r antagonist treatment for the reduction of cerebral edema and its consequences in both rodent and sheep models of stroke (Turner et al., 2006, 2011; Turner and Vink, 2012, 2014) and TBI (Donkin et al., 2009; Corrigan et al., 2012, 2016b; Vink et al., 2017). The gene discussed is TACR1; the disease is stroke disorder.