We observed that six genes (DCN, EMILIN1, FBLN5, FBN1, SGCD, and TGFB3) were hub genes in the brown co-expression module and were also located at the central hub of the PPI network generated using the STRING database, indicating that they may play an important role in the tumorigenesis and progression of BLCA. This evidence concerns the gene TGFB3 and bladder transitional cell carcinoma.