ABCA1 and atherosclerosis: HDL functions the efflux of cholesterol in macrophage-derived foam cells under angiothelium through ATP-binding cassette transporter G1 and ATP-binding cassette transporter A1 pathways, which has antiapoptotic, anti-inflammatory, and antioxidant effects against atherosclerosis.20 Therefore, patients with MetS are more prone to develop vascular lesions, which result in dysfunction of coagulation and higher blood loss during operations.