In contrast, decreased levels of RND3 results in reduced binding of RND3 to p65, decreased p65 ubiquitination and increased p65 protein expression, leading to activation of the NF‐κB signalling pathway and expression of its downstream target genes IL‐8 and BCL‐2, which can lead to apoptosis resistance in GBM cells (Figure 8). The gene discussed is BCL2; the disease is glioblastoma.