TAZ, also known as WWTR1 (WW-domain containing transcriptional regulator 1), a transcriptional coactivator with a PDZ-binding motif, and its paralog, yes-associated protein (YAP), are associated primarily with activity in the Hippo tumor suppressor pathway, which plays a prominent role in cell proliferation, cell apoptosis, tumor metastasis, and maintenance of stem cell traits in cancer [22–25]. This evidence concerns the gene WWTR1 and cancer.