In addition, an oncogenic role for USP39 has been reported in many malignant tumors, such as prostate cancer [10], oral squamous cell carcinoma [11], gastric cancer [12], melanoma [13], osteosarcoma [14], breast cancer [15], hepatocellular carcinoma [16], medullary thyroid carcinoma [17], lung cancer [18], pancreatic cancer [19], colorectal cancer [20], and renal cell carcinoma [21]. This evidence concerns the gene USP39 and cancer.