Membrane-bound FLT1 signaling has been well-characterized in peripheral vascular cells where it is known to facilitate inflammatory cell recruitment [35], but the recent recognition that FLT1 may be predominantly expressed in neurons [36] and glia [37] in AD brains raises the question of unidentified roles for this receptor in neural repair processes, particularly under conditions of systemic hypoxia. Here, FLT1 is linked to Alzheimer disease.