VEGFA and neoplasm: This expression pattern contrasts with the behaviour of angiogenic VEGFA-MEF2 driven enhancers in other adult tissues: both HLX-3:lacZ and Dll4in3:lacZ activity was reactivated during tumour neovascularization, neovascular growth into a matrigel plug, and neoangiogenesis in response to administration of adVEGFA into the mouse ear19 (Supplementary Figs. 8e and 20).