PPARGC1A and Dravet syndrome: To support this finding, we performed GSEA41 using a gene set of relevant transcriptional factors (TFs) regulating mitochondrial biogenesis, including PPARGC1A (PGC-1α), a master regulator of mitochondrial biogenesis7, PPARG (PPARgamma), TFAM, STAT3, TFB1M and FOXO142,43 showing these were significantly downregulated in DS (p < 0.001, FDR q < 0.001; Fig. 1d and Suppl.