TP73 and cholangiocarcinoma: Most studies have shown that positive immunohistochemical staining TP73 was associated with worse clinical outcome in extrahepatic bile duct carcinoma [19], cholangiocellular carcinoma [20], hepatocellular carcinoma [39,43], colorectal cancer [26,44], ovarian cancer [28] and esophageal squamous cell carcinoma [36].