Treatment with both SDF-1 and TGF-β1 increased CAM6, E-cad, and ZEB1 expressions (Figs 7I and S6C) and the resulting Ehi and E/M cell proportions (Fig 7J) in GFP-shRNA–expressing DCIS cells significantly more than did PBS. Here, CXCL12 is linked to ductal breast carcinoma in situ.