Inhibition of Src expression by shRNA significantly attenuated these observed inductions in DCIS cells treated with SDF-1 and TGF-β1 (Fig 7I and J), indicating Src to be required for induction of the Ehi and E/M states by stromal SDF-1 and TGF-β. The gene discussed is CXCL12; the disease is ductal breast carcinoma in situ.