Treatment with both SDF-1 and TGF-β1 strongly up-regulates CAM6, E-cad, and ZEB1 expressions (Fig 7I) and enhances the Ehi and E/M tumor cell proportions (Fig 7J) in DCIS cells through Src, leading to increased collective invasion (Fig 7L). The gene discussed is CXCL12; the disease is ductal breast carcinoma in situ.