Since ACTH and corticosterone levels are stress markers, not surprisingly, we found a strong linear relationship between anxiety levels and corticosterone r = 0.936 95% CI[0.856, 0.972], p < 0.0001 (Fig. 4B) as well as for ACTH r = 0.978 95% CI[0.948, 0.99], p < 0.0001 (Fig. 4C) levels. Here, POMC is linked to Anxiety.